Insights into structure and function of 30S Ribosomal Protein S2 (30S2) in Chlamydophila pneumoniae: A potent target of pneumonia

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• 作者：G. Koteswara Reddy^a ; ^{kotireddy.nit@gmail.com} ; K. Nagamalleswara Rao^b ; Kiran Yarrakula^a
• 关键词：Chlamydophila pneumoniae ; 30S ribosomal protein S2 ; Pneumonia ; Drug target ; Structure ; Function ; Ramachandran plot ; Profunc server
• 刊名：Computational Biology and Chemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：66
• 期：Complete
• 页码：11-20
• 全文大小：2887 K
• 卷排序：66

文摘

The protein 30S2 structure was modelled and validated by Ramachandran plot. Modelled protein has under most favoured “core” region to be found 88.7%. Modelled protein has an overall average score −0.20 obtained by G-factor statistics. Seven sequence motifs have been identified for 30S2 with reference codes (PR0095, PF0038, TIGR01012, PTHR11489, SSF52313 and PTHR11489). Seven structural highly conserved residues have been identified in the cleft with large volume 1288.83 Å3 and average depth of the cleft is 10.75 Å.