Identification of AaCASPS7, an effector caspase in Aedes albopictus
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- 作者：Lingyan Feng1 ; Hao Liu1 ; Xiaomei Li ; Jialu Qiao ; Shengya Wang ; Deyin Guo ; Qingzhen Liu ; qzhliu@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AaCASPS7 ; Aedes albopictus caspases7 ; Aadnr1 ; Aedes albopictus dnr1 ; Aamx ; Aedes albopictus mx ; Aaiap1 ; Aedes albopictus inhibitor of apoptosis protein 1 ; Aas7 ; Aedes albopictus ribosomal protein s7 ; AeCASPS7 ; Aedes aegypti caspase7 ; AeIAP1 ; Aedes aegypti inhibitor of apoptosis protein 1 ; bp ; base pair(s) ; Caspase(s) ; cysteine-containing aspartate-specific proteases ; cDNA ; DNA complementary to RNA ; DENV ; dengue virus ; DNase ; deoxyribonuclease ; DTT ; dithiothreitol ; drICE ; Drosophila melanogaster
- 刊名：Gene
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：593
- 期：1
- 页码：117-125
- 全文大小：1418 K
文摘
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AaCASPS7, an effector caspase from Aedes albopictus C6/36 cells was identified.
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Expression profiles of Aacasps7 during developmental and adult stages in Aedes albopictus mosquitoes were assayed.
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Caspase substrate specificity of AaCASPS7 was studied.
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Cleavage sites between the large subunit and the small subunit of AaCASPS7 were identified.
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Overexpression of AaCASPS7 induced caspase activity-dependent apoptosis in C6/36 cells.