Development of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicine
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- 作者：Mehmet Koray Gö ; ka ; mkgok@istanbul.edu.tr" class="auth_mail" title="E-mail the corresponding author ; Saadet Ö ; zgü ; mü ; şa ; Kamber Demirb ; Ü ; mü ; t Ciritc ; Serhat Pabuccuoğlub ; Erdal Cevherd ; Yıldız Ö ; zsoyd ; Sü ; leyman Bacınoğlue
- 关键词：Vaginal drug delivery ; Mucoadhesion ; Starch ; Acrylic acid ; Progesterone ; Estrus synchronization
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 January 2016
- 年：2016
- 卷：136
- 期：Complete
- 页码：63-70
- 全文大小：1134 K
文摘
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Mucoadhesive S-g-PAA was synthesized and characterized for vaginal applications.
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Mucoadhesive S-g-PAA based vaginal hormone delivery systems were first developed.
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These systems were evaluated in vitro and in vivo for the estrus synchronization.
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The hormone release profiles from these systems were compared with CR and CIDR.
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(WS-g-PAA)gc may be an alternative to these two commercial products.