Detection of dengue cases by serological testing in a dengue vaccine efficacy trial: Utility for efficacy evaluation and impact of future vaccine introduction
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- 作者：Eric Plennevauxa ; Eric.Plennevaux@sanofipasteur.com" class="auth_mail" title="E-mail the corresponding author ; Arunee Sabchareonb ; Kriengsak Limkittikulb ; Pornthep Chanthavanichb ; Chukiat Sirivichayakulb ; Annick Moureaua ; Mark Boazc ; T. Anh Warteld ; Melanie Savillea ; Alain Bouckenooghed
- 关键词：Flavivirus ; Dengue ; Vaccine ; Serology
- 刊名：Vaccine
- 出版年：2016
- 出版时间：23 May 2016
- 年：2016
- 卷：34
- 期：24
- 页码：2707-2712
- 全文大小：578 K
文摘
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Virologically-confirmed dengue cases serology profile in vaccine trial is described.
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We evaluated applicability of the WHO case definition for dengue in vaccine trials.
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False positives are common with dengue diagnosis based on IgM/IgG after vaccination.
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Lack of specificity and bias after vaccination limits IgM/IgG use for surveillance.
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Dengue diagnoses based on IgM/IgG need strengthening following vaccine introduction.