Genetic susceptibility for air pollution-induced airway inflammation in the SALIA study

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• 作者：Anke H&uuml ; ls^a ; ^{Anke.Huels@IUF-Duesseldorf.de} ; Ursula Krä ; mer^a ; Christian Herder^b ; ^c ; Karin Fehsel^d ; Christian Luckhaus^d ; Sabine Stolz^a ; Andrea Vierkö ; tter^a ; Tamara Schikowski^a
• 关键词：Gene-environment interactions ; Genetic risk scores ; Endoplasmatic reticulum (ER) stress ; Unfolded protein response (UPR)
• 刊名：Environmental Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：152
• 期：Complete
• 页码：43-50
• 全文大小：556 K
• 卷排序：152

文摘

SNPs of the ER stress pathway are involved in inflammation processes in the lung. Association between air pollution and airway inflammation is modified by ER stress. Higher susceptibility for women who are carriers of the ER stress risk alleles. The strongest gene-environment interaction was found for LTB4.