Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in?vitro and in?vivo

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• 作者：Engin Ulukaya^a ; ^{eulukaya@uludag.edu.tr} ; Ferda Ari^b ; Konstantinos Dimas^c ; Elif Ilkay Ikitimur^d ; Emel Guney^e ; Veysel T. Yilmaz^e
• 关键词：Palladium(II) complex ; Breast cancer ; Cytotoxicity ; Apoptosis ; Treatment
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2011
• 出版时间：October, 2011
• 年：2011
• 卷：46
• 期：10
• 页码：4957-4963
• 全文大小：761 K

文摘

Anti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)¡¤4H₂O (sac?=?saccharinate, and terpy?=?2,2¡ä:6¡ä,2¡å-terpyridine), were tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. The Pd complex had a strong anti-growth effect in a dose- and time-dependent manner in?vitro. This effect was also confirmed by the experiment performed on Balb/c mice in?vivo. The IC₅₀ values were 0.09?¦ÌM for MDA-MB-231 and 3.05?¦ÌM for MCF-7. It was also very effective in disrupting the formation of MDA-MB-231 tubules on matrigel, indicative of a putative anti-invasive activity. It induced apoptosis via the cell death genes of DR4 and DR5. In conclusion, this newly-synthesized Pd (II) complex represents a potentially active novel drug for the breast cancer treatment.