Structural pierce into molecular mechanism underlying Clostridium perfringens Epsilon toxin function

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• 作者：Saeed Khalili^a ; Abolfazl Jahangiri^a ; Zahra Sadat Hashemi^b ; Bahman Khalesi^c ; Maysam Mard-Soltani^d ; Jafar Amani^a ; ^{jafar.amani@gmail.com}
• 关键词：Clostridium perfringens ; Epsilon toxin ; Structure modeling ; Molecular dynamics ; Protein docking
• 刊名：Toxicon
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：90-99
• 全文大小：2965 K
• 卷排序：127

文摘

MAL and HAVCR1 are the key receptors of the E-toxin. E-toxin could convey its function through 3 possible models. MAL seems to be the key receptor which influences the fate of the toxin action mechanism. MAL could guide the toxin through a prepore stage or even independent from a pore.