Oral pharmacokinetics of baicalin, wogonoside, oroxylin A 7-O-β-d-glucuronide and their aglycones from an aqueous extract of Scutellariae Radix in the rat
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- 作者：Yu Cai ; Sai Li ; Ting Li ; Ruina Zhou ; Alfred Tai-Seng Wai ; Ru Yan ; ruyan@umac.mo" class="auth_mail" title="E-mail the corresponding author
- 关键词：Scutellaria Radix ; Systemic exposure ; Microbial metabolism ; Hepatic glucuronidation ; Isomerization ; Intestinal permeability
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：1026
- 期：Complete
- 页码：124-133
- 全文大小：1984 K
文摘
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Oral systemic exposure of six flavonoids in extract and isomers formed was reported.
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Microbial and liver metabolism, and intestinal permeability varied with structure.
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OG and wogonin were the highest glucuronide and aglycone, respectively, in vivo.
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Microbial isomerization of BG and glucuronidation of baicalein formed BG 6-isomer.
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A minor BG isomer might originate from microbial hydrolysis and demethylation of WG.