Facile and controllable synthesis of multiply substituted benzenes via a formal [3+3] cycloaddition approach

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• 作者：Zhen-Cao Shu ; Jian-Bo Zhu ; Saihu Liao ; Xiu-Li Sun ; Yong Tang ; ^{tangy@sioc.ac.cn}
• 关键词：Multi-substituted benzenes ; ¦Á ; ¦Â-Unsaturated ketones ; Formal [3+3] cycloaddition ; Aromatization
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：7 January, 2013
• 年：2013
• 卷：69
• 期：1
• 页码：284-292
• 全文大小：1828 K

文摘

A facile direct [3+3] approach for the conversion of ¦Á,¦Â-unsaturated carbonyls to multi-substituted benzenes using allylic phosphonium ylide reagents has been developed. The substituents and their positions on the benzene ring are controllable and predictable by the choice of an appropriate combination of ¦Á,¦Â-unsaturated carbonyl compounds and ylides.