Effects of Dai-saiko-to (Da-Chai-Hu-Tang) on plasma lipids and atherosclerotic lesions in female heterozygous heritable Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits

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• 作者：Yoshie ; Fumihiko ; Iizuka ; Akira ; Komatsu ; Yasuhiro ; Matsumoto ; Akiyo ; Itakura ; Hiroshige ; Kondo ; Kazuo
• 关键词：Dai-saiko-to ; Pravastatin ; Heterozygous KHC rabbit ; LDL-receptor mRNA
• 刊名：Pharmacological Research
• 出版年：2004
• 出版时间：September, 2004
• 年：2004
• 卷：50
• 期：3
• 页码：223-230
• 全文大小：318 K

文摘

We investigated the antihypercholesterolemic effects of traditional Japanese herbal medicine Dai-saiko-to (Da-Chai-Hu-Tang in Chinese) in female heritable Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. The plasma total cholesterol levels increased for up to 12 weeks after beginning a diet containing 0.1 % cholesterol then reached a plateau of about 603mgdl⁻¹. Dai-saiko-to was administered at doses of 0.5–1.0gkg⁻¹ per day or pravastatin 10mgkg⁻¹ per day for 24 weeks. Plasma total cholesterol levels were significantly decreased in the groups administered Dai-saiko-to 1.0gkg⁻¹ per day or pravastatin for 4–24 weeks, whereas there were no change with plasma phospholipid and triglyceride levels. However, Dai-saiko-to 1.0gkg⁻¹ per day significantly decreased plasma LDL cholesterol levels, but had no effect on either VLDL- or HDL-cholesterol levels.