Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats

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• 作者：Taira ; Zenei ; Yabe ; Kazunori ; Hamaguchi ; Yuka ; Hirayama ; Kensuke ; Kishimoto ; Makoto ; Ishida ; Shiro ; et. al.
• 关键词：Sho-saiko-to extract ; Salicylamide ; Pharmacokinetics ; Carbon tetrachloride ; Hepatic injury
• 刊名：Food and Chemical Toxicology
• 出版年：2004
• 出版时间：May, 2004
• 年：2004
• 卷：42
• 期：5
• 页码：803-807
• 全文大小：165 K

文摘

To elucidate the effects of Sho-saiko-to extract and its components, baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, against the effects of longer periods of acute hepatic injury induced by CCl₄, we measured serum ALT activity in male Wistar rats for five days after ip administration of CCl₄ (0.2 ml/kg), and examined the daily changes of the pharmacokinetic behavior of salicylamide (SAM) for five days. Serum ALT activity rose to a maximum level within a day after administration of CCl₄ and then decreased to the control level after three. Sho-saiko-to extract and its components could suppress this acute change in serum ALT activity to less than 50 % of CCl₄ alone. However, the pharmacokinetics of SAM showed that liver function recovers in a biphasic manner, so that plasma clearance (CL) decreased significantly at days 1 and 3 after administration of CCl₄ (P<0.05). We concluded that the CL change at day 1 corresponds to the acute action of CCl₄ intoxication, and that the change at day 3 is effect of physiologically reduced liver function due to the liver regeneration for tissue repair after the CCl₄ hepatic injury. Sho-saiko-to extract and its components were shown to suppress acute hepatic injury induced by CCl₄, and to bring about an early recovery in liver function.