Nuclear expression of IL-33 in epidermal keratinocytes promotes wound healing in mice

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• 作者：Tomoyuki Oshio ; Ph.D.^a ; ^{kiyumoto-oshio@hotmail.co.jp} ; Mayumi Komine ; M.D. Ph.D.^a ; ^b ; ^{mkomine12@jichi.ac.jp} ; Hidetoshi Tsuda ; Ph.D.^a ; ^{thidet@jichi.ac.jp} ; Shin-ichi Tominaga ; M.D. Ph.D.^b ; ^{shintomi@jichi.ac.jp} ; Hirohisa Saito ; M.D. Ph.D.^c ; ^{saito-hr@ncchd.go.jp} ; Susumu Nakae ; M.D. Ph.D.^d ; ^{snakae@ims.u-tokyo.ac.jp} ; Mamitaro Ohtsuki ; M.D. Ph.D.^a ; ^{mamitaro@jichi.ac.jp}
• 关键词：IL-33 ; Nuclear expression ; Wound healing ; Keratinocytes ; Epithelialization
• 刊名：Journal of Dermatological Science
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：85
• 期：2
• 页码：106-114
• 全文大小：2918 K
• 卷排序：85

文摘

IL-33 is positively involved in wound healing. IL-33 involvement in wound healing is dependent on nuclear factor kappa B. Nuclear IL-33, but not IL-33 as a cytokine, is involved in wound healing. IL-33 involvement in wound healing is also dependent on re-epithelialization process of keratinocytes.