Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility
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- 作者：James A. Nieman ; Sajiv K. Nair ; Steven E. Heasley ; Brenda L. Schultz ; Herbert M. Zerth ; Richard A. Nugent ; Ke Chen ; Kevin J. Stephanski ; Todd A. Hopkins ; Mary L. Knechtel ; Nancee L. Oien ; Janet L. Wie
- 关键词：Pyrroloquinoline ; Cytomegalovirus ; HCMV ; Varicella-zoster ; Herpesvirus
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2010
- 出版时间：15 May 2010
- 年：2010
- 卷：20
- 期：10
- 页码：3039-3042
- 全文大小：580 K
文摘
A series of C-2 pyrroloquinoline analogs designed to improve aqueous solubility were examined for herpesvirus polymerase and antiviral activity. Several analogs were identified that maintained the antiviral activity of the previous development candidate against HCMV, HSV-1 and VZV, but with significantly improved aqueous solubility.