The incidence of deep vein thrombosis in Japanese patients undergoing endoscopic submucosal dissection

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• 作者：Masafumi  ; Kusunoki MD¹ ; Kazumasa  ; Miyake MD ; PhD¹ ;   ; ; Tomotaka  ; Shindo MD ; PhD¹ ; Nobue  ; Ueki MD ; PhD¹ ; Tetsuro  ; Kawagoe MD ; PhD¹ ; Katya  ; Gudis PhD¹ ; Seiji  ; Futagami MD ; PhD¹ ; Taku  ; Tsukui MD ; PhD¹ ; Ikuyo  ; Takagi MD ; PhD² ; Junro  ; Hosaka MD ; PhD³ ; Choitsu  ; Sakamoto MD ; PhD¹
• 刊名：Gastrointestinal Endoscopy
• 出版年：2011
• 出版时间：October 2011
• 年：2011
• 卷：74
• 期：4
• 页码：798-804
• 全文大小：675 K

文摘

Background

Endoscopic submucosal dissection (ESD) is more invasive than other common endoscopic procedures and may increase the risk for deep vein thrombosis (DVT)/pulmonary embolism. The incidence of DVT/pulmonary embolism after ESD has not been adequately studied.

Objective

To evaluate DVT incidence and disease-specific features of D-dimer levels in ESD patients.

Design

Prospective cohort study.

Setting

Single academic center.

Patients

This study involved 60 patients with superficial gastric neoplasms indicated for ESD.

Intervention

For all patients who underwent ESD, ultrasonography of the lower limbs was performed to detect DVT the day after ESD. D-dimer levels were measured 3 times: before ESD, immediately after ESD, and the day after ESD.

Main Outcome Measurements

DVT incidence after ESD.

Results

The DVT incidence was 10.0 % (6/60). At all 3 time points, D-dimer measurements were higher in patients with DVT than in patients without DVT. According to receiver operating characteristic curve analysis, the resulting cut-off value of the D-dimer level the day after ESD was 1.9 ¦Ìg/mL (sensitivity 83.3 % ; specificity 79.6 % ) for ESD patients, with superior association to pre-ESD or immediately after ESD. In univariate analyses, high D-dimer levels the day after ESD and the presence of comorbidities were significantly associated with DVT development.

Limitations

Single center and small number of patients.

Conclusion

ESD procedures have a moderate risk for venous thromboembolism. In patients undergoing ESD, D-dimer levels, especially on the day after ESD, may have specific features associated with DVT development.