A ¦Ä-Zr-hydride was irradiated with 6.4 MeV Fe3+ ions to clarify the relationship between hardening and microstructural changes of bulk Zr-hydrides under neutron irradiation. Irradiation hardening was measured by nanoindentation tests. Transmission electron microscope cross-sectional observations showed that the deformation mechanism of the ¦Ä-Zr-hydride was both slip and twinning. Dislocation loops were observed in the irradiated hydride matrix. These irradiation-induced defects make slip deformation difficult and consequently promote the twin deformation of ¦Ä-Zr-hydride. This work is a continuation of the previous our work (J. Nucl. Mater. 419 (2011) 366-370) focused upon ¦Å-Zr-hydride and we discuss a comparison between the two Zr-hydrides.