Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines

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• 作者：Kenichi Takayasu¹ ; ^&dagger ; ; ^{ktakayas@ncc.go.jp} ; Shigeki Arii² ; ^&dagger ; ; Masatoshi Kudo³ ; ^&dagger ; ; Takafumi Ichida⁴ ; ^&dagger ; ; Osamu Matsui⁵ ; ^&dagger ; ; Namiki Izumi⁶ ; ^&dagger ; ; Yutaka Matsuyama⁷ ; ^&dagger ; ; Michiie Sakamoto⁸ ; ^&dagger ; ; Osamu Nakashima⁹ ; ^&dagger ; ; Yonson Ku¹⁰ ; ^&dagger ; ; Norihiro Kokudo¹¹ ; ^&dagger ; ; Masatoshi Makuuchi¹² ; ^&dagger ;
• 关键词：Hepatocellular carcinoma (HCC) ; Transcatheter arterial chemoembolization (TACE) ; Prognostic factor ; Validation of treatment algorithm ; Japanese guidelines
• 刊名：Journal of Hepatology
• 出版年：2012
• 出版时间：April, 2012
• 年：2012
• 卷：56
• 期：4
• 页码：886-892
• 全文大小：973 K

文摘

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Background & Aims

Transcatheter arterial chemoembolization with lipiodol (TACE) is widely performed in patients with hepatocellular carcinoma (HCC) unsuitable for curative treatment. It has recently been recommended for patients with 2 or 3 tumors >3 cm or ? tumors in a treatment algorithm proposed by Japanese guidelines. However, the best indication and appropriateness of the algorithm for TACE are still unclear.

Methods

In 4966 HCC patients who underwent TACE, survival was evaluated based on tumor number, size and liver function; and the adequacy of the algorithm for TACE was validated. Exclusion criteria were: vascular invasion, extrahepatic metastasis, and prior treatment. The mean follow up period was 1.6 years.

Results

The overall median and 5-year survivals were 3.3 years and 34 % , respectively. Multivariate analysis revealed that Child-Pugh class, tumor number, size, alpha-fetoprotein, and des-gamma carboxy-prothrombin were independent predictors. The survival rate decreased as the tumor number (p = 0.0001) and size increased (p = 0.04 to p = 0.0001) in all but one subgroup in both Child-Pugh-A and -B. The stratification of these patients to four treatments in the algorithm showed potential ability to discriminate survivals of the resection and ablation (non-TACE) groups from those of the TACE group in Child-Pugh-B and partially in A.

Conclusions

TACE showed higher survival rates in patients with fewer tumor numbers, smaller tumor size, and better liver function. The treatment algorithm proposed by the Japanese guidelines might be appropriate to discriminate the survival of patients with non-TACE from TACE therapy.