Silodosin vs tamsulosin in the management of distal ureteric stones: A prospective randomised study

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• 作者：Hazem Elgalaly ; Ahmed Sakr ; Amr Fawzi ; Emad A. Salem ; Esam Desoky ; Ashraf Shahin ; Mostafa Kamel ; ^{mamar1973@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：DUS ; distal ureteric stones ; KUB ; plain abdominal radiograph of the kidneys ; ureters and bladder ; MET ; medical expulsive therapy ; SWL ; shockwave lithotripsy
• 刊名：Arab Journal of Urology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：14
• 期：1
• 页码：12-17
• 全文大小：574 K

文摘

To compare the efficacy of silodosin (8 mg) vs tamsulosin (0.4 mg), as a medical expulsive therapy, in the management of distal ureteric stones (DUS) in terms of stone clearance rate and stone expulsion time.

Patients and methods

A prospective randomised study was conducted on 115 patients, aged 21–55 years, who had unilateral DUS of ⩽10 mm. Patients were divided into two groups. Group 1 received silodosin (8 mg) and Group 2 received tamsulosin (0.4 mg) daily for 1 month. The patients were followed-up by ultrasonography, plain abdominal radiograph of the kidneys, ureters and bladder, and computed tomography (in some cases).

Results

There was a significantly higher stone clearance rate of 83% in Group 1 vs 57% in Group 2 (P = 0.007). Group 1 also showed a significant advantage for stone expulsion time and analgesic use. Four patients, two in each group, discontinued the treatment in first few days due to side-effects (orthostatic hypotension). No severe complications were recorded during the treatment period. Retrograde ejaculation was recorded in nine and three patients in Groups 1 and 2, respectively.

Conclusion

Our data show that silodosin is more effective than tamsulosin in the management of DUS for stone clearance rates and stone expulsion times. A multicentre study on larger scale is needed to confirm the efficacy and safety of silodosin.