The melanocortin ACTH 1-39 promotes protection of oligodendrocytes by astroglia
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- 作者：Robert P. Lisak1 ; Liljana Nedelkoska ; Joyce A. Benjamins ; 1 ; jbenjami@med.wayne.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Astroglia ; Conditioned medium ; Excitotoxicity ; Inflammation ; Melanocortin receptors ; Multiple sclerosis ; Oligodendroglia ; Protection ; Reactive oxygen species
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：362
- 期：Complete
- 页码：21-26
- 全文大小：801 K
文摘
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Conditioned medium from ACTH-treated astroglia protects oligodendroglia from glutamate, NMDA, AMPA, quinolinic acid and ROS.
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These results are comparable to our previous results with ACTH itself, except ACTH also protected from kainate and staurosporine.
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Conditioned medium from astroglia and microglia not treated with ACTH, or from microglia treated with ACTH did not protect from the toxic agents.
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The cellular mechanisms underlying the protective effects of ACTH for oligodendroglia are complex, varying with the toxic agents.