Conditioned medium from ACTH-treated astroglia protects oligodendroglia from glutamate, NMDA, AMPA, quinolinic acid and ROS.
These results are comparable to our previous results with ACTH itself, except ACTH also protected from kainate and staurosporine.
Conditioned medium from astroglia and microglia not treated with ACTH, or from microglia treated with ACTH did not protect from the toxic agents.
The cellular mechanisms underlying the protective effects of ACTH for oligodendroglia are complex, varying with the toxic agents.