Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway
详细信息 查看全文
- 作者：Pouria Heydarpoura ; b ; 1 ; Reza Rahimiana ; c ; 1 ; Gohar Fakhfouric ; d ; Shayan Khoshkisha ; b ; Nahid Fakhraeib ; Mohammad Salehi-Sadaghiania ; b ; Hongxing Wange ; Ata Abbasif ; Ahmad Reza Dehpoura ; g ; Jean-Eric Ghiae ; h ; jean-eric.ghia@umanitoba.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer&rsquo ; s disease ; (AD) ; Aminoguanidine hydrochloride ; (AG) ; Analysis of variance ; (ANOVA) ; Autonomic nervous sytem ; (ANS) ; Bovine serum albumin ; (BSA) ; Central nervous system ; (CNS) ; Central nucleus of the amygdala ; (CeA) ; Corticotropin-releasing factor ; (CRF) ; Crohn&rsquo ; s disease ; (CD) ; Dextran sulfate sodium ; (DSS) ; Ethylenediaminetetraacetic acid ; (EDTA) ; Forced swimming test ; (FST) ; Inducible nitric oxide synthase ; (iNOS) ; Inflammatory bowel diseases ; (IBD) ; Intraperitoneal ; (i.p.
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：4 January 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：131-141
- 全文大小：1520 K
文摘
- •
Colitis in mice is accompanied by an increase in the severity of behavioral despair.
- •
Hippocampal iNOS, TNF-alpha and nitrite level are up-regulated.
- •
NOS & iNOS inhibitors attenuated the behavioral despair and central markers studied.