Caspases and immunity in a deadly grip

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• 作者：Ian G. Rodrigue-Gervais¹ ; Maya Saleh¹ ; ² ; ^{maya.saleh@mcgill.ca}
• 关键词：caspase ; apoptosis ; necroptosis ; inflammation ; immunity
• 刊名：Trends in Immunology
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：34
• 期：2
• 页码：41-49
• 全文大小：1165 K

文摘

Caspases are crucial for the execution of apoptotic cell death. However, caspase-1, the first identified mammalian caspase, was not discovered in the context of apoptosis, but rather as an enzyme that processes the proinflammatory cytokine interleukin (IL)-1¦Â. More recently, additional nonapoptotic roles of apoptotic caspases have been uncovered. For example, caspase-8 can counteract necroptosis, an inflammatory mode of cell death induced by receptor-interacting protein (RIP)3. Here, we explore how caspases and their associated proteins and substrates mediate multiple cellular immune processes that extend beyond cell death. We focus on caspases-1, -8 and -11 because of the growing excitement in considering these caspases through the lens of regulators of immunity rather than primarily as arbiters of cell fate.