Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells
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- 作者：Ferdinand von Meyenn1 ; 10 ; Mario Iurlaro1 ; 10 ; Ehsan Habibi2 ; 10 ; Ning Qing Liu2 ; Ali Salehzadeh-Yazdi3 ; 12 ; Fá ; tima Santos1 ; Edoardo Petrini1 ; Inê ; s Milagre1 ; Miao Yu4 ; 5 ; Zhenqing Xie6 ; Leonie I. Kroeze7 ; Tatyana B. Nesterova8 ; Joop H. Jansen7 ; Hehuang Xie6 ; Chuan He4 ; 5 ; Wolf Reik1 ; 9 ; 11 ; wolf.reik@babraham.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Hendrik G. Stunnenberg2 ; 11 ; h.stunnenberg@ncmls.ru.nl" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：16 June 2016
- 年：2016
- 卷：62
- 期：6
- 页码：848-861
- 全文大小：3173 K
文摘
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Impaired DNA methylation maintenance is the cause of global demethylation in naive ESCs
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Loss of H3K9me2 and UHRF1 lead to impaired maintenance targeting to replication foci
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TET enzymes are not required for global demethylation
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Mathematical model accurately predicts global 5mC and 5hmC during epigenetic resetting