Reduction in necrotising enterocolitis after implementing an evidence-based enteral nutrition protocol in very low birth weight newborns

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• 作者：Tomá ; s Sá ; nchez-Tamayo ; ^{tomas.sanchez.tamayo@gmail.com} ; Marí ; a Gracia Espinosa Ferná ; ndez ; Laura Affumicato ; Marí ; a Gonzá ; lez Ló ; pez ; Veró ; nica Ferná ; ndez Romero ; Marí ; a Concepció ; n Moreno Algarra ; Enrique Salguero Garcí ; a
• 关键词：Enteral nutrition ; Necrotising enterocolitis ; Very low birth weight infant ; Premature infant ; Prevention ; Practice guideline ; Bowel perforation ; Trophic feeding
• 刊名：Anales de Pediatría (English Edition)
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：85
• 期：6
• 页码：291-299
• 全文大小：562 K
• 卷排序：85

文摘

An unexpected increase in the incidence of necrotising enterocolitis (NEC) cases was observed in our hospital. Just in case, our feeding policy could be responsible, it was decided to conduct a systematic review and develop a clinical guideline regarding enteral nutrition of very low birth weight infants (VLBW).ObjectiveTo assess the impact of the new feeding protocol in the incidence of NEC.MethodA “before” (2011) and “after” (May 2012–April 2013) study was performed on the new feeding protocol. This included initiation of enteral feeding in the absence of haemodynamic problems, a trophic feeding period of 5–7 days, and subsequent increments of 20–30 mL/kg/day, of breast milk/donor human milk from the beginning. Probiotics were not administered. Primary outcome: incidence of NEC II 2 Bell's stage. Secondary outcomes: focal intestinal perforation, overall mortality and mortality due to NEC, nosocomial sepsis; weight at 28 days and 36 weeks; % of infants with weight p < 10 at discharge; and length of stay.ResultsOf the 270 VLBW infants, 155 were included in the “before” group, and 115 in the “after” group. NEC significantly decreased (12/155 vs 1/115, p = .008). A decrease in mortality rate was also observed (17.4% vs 7.8%, p = .02). In four cases NEC was part of the sequence of events that led to death in the first cohort, with none in the second. There was no difference in the incidence of focal intestinal perforation or of the other secondary variables analysed.ConclusionsImplementation of an evidence-based enteral feeding protocol leads to a decrease in incidence of NEC, without increasing hospital stay or the incidence of sepsis.