M2SR, a novel live single replication influenza virus vaccine, provides effective heterosubtypic protection in mice
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- 作者：Sally Sarawara ; Yasuko Hattab ; Shinji Watanabec ; Peter Diasa ; Gabriele Neumannc ; Yoshihiro Kawaokac ; d ; Pamuk Bilselb ; pbilsel@flugen.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADCC ; antibody-dependent cellular cytotoxicity ; Aichi ; influenza A/Aichi/2/1968 ; APC ; allophycocyanin ; BAL ; bronchoalveolar lavage ; BSA ; bovine serum albumin ; CPE ; cytopathic effect ; FCS ; fetal calf serum ; FITC ; fluorescein isothiocyanate ; HAI ; hemagglutination inhibition ; IFN ; interferon ; IN ; intranasal ; IM ; intramuscular ; IP ; intraperitoneal ; LAIV ; live attenuated influenza vaccine ; LDS ; lithium dodecyl sulfate ; LOD ; limit of detection ; M2SR ; M2-deficient single replication vaccine virus ; M2CK
- 刊名：Vaccine
- 出版年：2016
- 出版时间：30 September 2016
- 年：2016
- 卷：34
- 期：42
- 页码：5090-5098
- 全文大小：890 K
文摘
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M2SR is an M2-deleted Single Replication novel influenza vaccine.
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M2SR provides homosubtypic and heterosubtypic protection in mice.
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M2SR elicits cross-reactive T cell responses recalled upon heterosubtypic challenge.