The Mitochondrial Lon Protease Is Required for Age-Specific and Sex-Specific Adaptation to Oxidative Stress

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• 作者：Laura C.D. Pomatto¹ ; Caroline Carney¹ ; Brenda Shen¹ ; Sarah Wong¹ ; Kelly Halaszynski¹ ; Matthew P. Salomon² ; ³ ; Kelvin J.A. Davies¹ ; ² ; John Tower¹ ; ² ; ⁴ ; ^{jtower@usc.edu}
• 关键词：aging ; mitochondria ; adaptation ; Lon ; transformer ; oxidative stress ; hydrogen peroxide ; hormesis ; paraquat ; sexual differentiation
• 刊名：Current Biology
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：27
• 期：1
• 页码：1-15
• 全文大小：4095 K
• 卷排序：27

文摘

Female-specific H2O2 and male-specific paraquat stress adaptation require Lon Sex-specific expression of Lon protein isoforms Sex-specific Lon expression and stress adaption are regulated by transformer Sex-specific expression of Lon isoforms is observed in mammalian tissues