Development of a multi-matrix LC-MS/MS method for urea quantitation and its application in human respiratory disease studies

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• 作者：Jianshuang Wang^a ; ^{wang.jianshuang@gene.com} ; Yang Gao^b ; Drew W. Dorshorst^b ; Fang Cai^c ; Meire Bremer^c ; Dennis Milanowski^b ; Tracy L. Staton^c ; Stephanie S. Cape^b ; Brian Dean^a ; Xiao Ding^a
• 关键词：Bioanalysis ; Urea ; LC&ndash ; MS/MS ; Volume normalization ; Respiratory disease
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：133
• 期：Complete
• 页码：96-104
• 全文大小：1302 K
• 卷排序：133

文摘

Sample volume normalization by urea concentration ratio in support of human respiratory disease studies. A simple and reliable multi-matrix LC–MS/MS method for absolute quantitation of urea. Salting-out assisted liquid-liquid extraction of extremely polar small molecule.