Serum salusin-alpha level in rheumatoid arthritis

详细信息    查看全文

• 作者：Metin Ozgen^a ; Suleyman Serdar Koca^a ; ^{kocassk@yahoo.com} ; Necati Dagli^b ; Mehmet Balin^c ; Bilal Ustundag^d ; Ahmet Isik^a
• 关键词：Salusin-α ; Atherosclerosis ; Rheumatoid arthritis ; Behcet's disease
• 刊名：Regulatory Peptides
• 出版年：2011
• 出版时间：25 February 2011
• 年：2011
• 卷：167
• 期：1
• 页码：125-128
• 全文大小：139 K

文摘

Rheumatoid arthritis (RA), a chronic inflammatory disease, leads to early and accelerated atherosclerosis; however, its pathogenesis is not yet fully documented. Salusin-α and β are novel bioactive peptides. Salusin-α suppresses macrophage foam cell formation, while salusin-β stimulates. Moreover, decreased serum salusin-α level has been reported previously in patients with coronary artery disease. The aims of the study were to assess serum salusin-α level and its association with predictors of atherosclerosis in a cohort of patients with RA.

The study included 56 RA patients, 37 Behcet's disease (BD) patients, and 29 healthy controls (HC). TNF-α, IL-6 and salusin-α levels, homeostasis model assessment (HOMA-IR) index and common carotid intima-media thickness (IMT) were determined.

In the RA and BD groups, salusin-α levels (p < 0.001 and p < 0.01, respectively) and IMTs (p < 0.001 for both) were higher compared to the HC group. However, the level of salusin-α was not directly associated with the IMT in all the groups.

Serum salusin-α levels are increased in RA and BD, although they have increased IMT. Salusin-α has been reported to have anti-atherogenic effects in previous studies. However, it seems that salusin-α does not directly affect the atherogenesis in RA and BD. Further studies are needed to understand the regulation of salusin-α and determination of its relations with the predictors of atherosclerosis in RA and BD.