Clinical and hemodynamic outcomes of ¡°all-comers¡± undergoing?transapical aortic valve implantation: Results from?the Italian Registry of Trans-Apical Aortic?Valve Implantation (I-TA)

详细信息    查看全文

• 作者：Augusto D&rsquo ; Onofrio ; MD^a ; ^{adonofrio@hotmail.it} ; Paolo Rubino ; MD^b ; Melissa Fusari ; MD^c ; Loris Salvador ; MD^d ; Francesco Musumeci ; MD^e ; Mauro Rinaldi ; MD^f ; Ettore O. Vitali ; MD^g ; Mattia Glauber ; MD^h ; Roberto Di Bartolomeo ; MDⁱ ; Ottavio R. Alfieri ; MD^j ; Elvio Polesel ; MD^k ; Marco Aiello ; MD^l ; Riccardo Casabona ; MD^m ; Ugolino Livi ; MDⁿ ; Claudio Grossi ; MD^o ; Mauro Cassese ; MD^p ; Aniello Pappalardo ; MD^q ; Tiziano Gherli ; MD^r ; Guglielmo Stefanelli ; MD^s ; Giuseppe G. Faggian ; MD^t ; Gino Gerosa ; MD^a
• 关键词：35.2 ; 35.3.5
• 刊名：The Journal of Thoracic and Cardiovascular Surgery
• 出版年：2011
• 出版时间：October, 2011
• 年：2011
• 卷：142
• 期：4
• 页码：768-775
• 全文大小：353 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Objective

The aim of this study was to assess clinical and hemodynamic outcomes of transapical aortic valve implantation (TA-TAVI) in patients enrolled in the Italian Registry of Trans-Apical Aortic Valve Implantation (I-TA).

Methods

From April 2008 until November 2010, 504 patients from 20 Italian centers were enrolled in the I-TA registry. Mean logistic EuroSCORE and Society of Thoracic Surgeons score were 24 % ¡À 16 % and 11 % ¡À 4 % , respectively. Mean follow-up was 9.2 ¡À 6.5 months (range, 1-26 months). Outcomes were analyzed according to intraoperative complications, procedural volume (high-volume centers, >20 cases; low-volume centers,?<?20 cases) and learning curve (first 50 % cases vs second 50 % cases of each center).

Results

All-cause overall mortality was 8.3 % (42 patients). Device success was 99 % (500/504 patients). Intraoperative severe complications occurred in 24 (4.8 % ) patients. Overall 2-year survival was 71.5 % ¡À 6.2 % . At discharge, peak and mean gradients were 16.4 ¡À 11.2 and 8.7 ¡À 4.1 mm Hg, respectively, and effective orifice area was 1.67 cm². These values remained stable at 3, 6, and 12 months after surgery. Independent risk factors for mortality after TA-TAVI were as follows: New York Heart Association class III and IV (odds ratio [OR], 4.43; 95 % confidence intervals [CI], 1.28-15.40; P?=?.02); logistic EuroSCORE greater than 20 (OR, 1.83; 95 % CI, 1.02-3.29; P?=?.04); creatinine concentration greater than 200 ¦Ìmol/L (OR, 2.56; 95 % CI, 1.07-6.15; P?=?.03), and intraoperative complications (OR, 5.80; 95 % CI, 2.68-12.55; P?<?.001). There were no significant differences in outcomes between high- and low-volume centers and between the first and the second 50 % of cases.

Conclusions

TA-TAVI represents a safe and effective alternative treatment for patients who are inoperable or at high risk for surgery. The occurrence of an intraoperative complication significantly affects survival. Procedural volume and learning curve have no impact on patient survival.