Leucotrichoic acid, a novel sesquiterpene from Sinningia leucotricha (Gesneriaceae)
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- 作者：Maria Helena Verdan ; Lilian K. Unemoto ; Ricardo T. Faria ; Marcos Jos¨¦ Salvador ; Eduardo Lemos de S¨¢ ; Andersson Barison ; Maria Elida A. Stefanello
- 关键词：Gesneriaceae ; Sinningia ; Sesquiterpene ; Triquinane ; NMR
- 刊名：Tetrahedron Letters
- 出版年：2013
- 出版时间：28 August, 2013
- 年：2013
- 卷：54
- 期：35
- 页码：4735-4737
- 全文大小：497 K
文摘
Chemical investigation of Sinningia leucotricha (Gesneriaceae) resulted in the isolation of leucotrichoic acid, a sesquiterpene with a novel triquinane skeleton, and the known triterpenes hederagenin and 23-hydroxyursolic acid. The chemical structures of all compounds were elucidated through spectroscopic analysis (NMR and MS). The conformational stability of the new compound was analyzed by density theory functional methods. A possible biogenesis for the new compound is proposed. Leucotrichoic acid was inactive against a panel of human cancer cell lines.