Tuberculosis unleashed: the impact of human immunodeficiency virus infection on the host granulomatous response to Mycobacterium tuberculosis

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• 作者：Lawn ; Stephen D. ; Butera ; Salvatore T. ; Shinnick ; Thomas M.
• 关键词：Tuberculosis ; Mycobacterium tuberculosis ; Human immunodeficiency virus type 1 ; Granuloma ; Cell-mediated immunity
• 刊名：Microbes and Infection
• 出版年：2002
• 出版时间：May, 2002
• 年：2002
• 卷：4
• 期：6
• 页码：635-646
• 全文大小：413 K

文摘

The granuloma plays a critical role in the host immune response to Mycobacterium tuberculosis, containing the organism and confining it in a latent state in most infected individuals. Indeed, approximately one-third of the world’s population has latent M. tuberculosis infection. However, over the past decade, the human immunodeficiency virus type 1 (HIV-1) pandemic has profoundly affected the incidence and clinicopathological features of tuberculosis. This review examines the immunological mechanisms whereby HIV-1 impairs the establishment, maintenance and function of the tuberculous granuloma.