DAS181 for Treatment of Parainfluenza Virus Infections in Hematopoietic Stem Cell Transplant Recipients at a Single Center
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- 作者：Mirella Salvatore1 ; mis2053@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author ; Michael J. Satlin1 ; Samantha E. Jacobs1 ; Stephen G. Jenkins2 ; Audrey N. Schuetz2 ; Ronald B. Moss3 ; Koen Van Besien1 ; Tsiporah Shore1 ; Rosemary Soave1
- 关键词：DAS181 ; Parainfluenza virus ; Hematopoietic stem cell transplant ; Pneumonia
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：22
- 期：5
- 页码：965-970
- 全文大小：151 K
文摘
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We used DAS181, a sialidase protein, to treat parainfluenza infection in 16 hematopoietic stem cell transplant patients
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All patients presented with cough, 14 had dyspnea, 11 had hypoxia, and 8 had a fever
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Nine patients had a complete response and 4 had a partial response to DAS181
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The 3 patients without clinical response had coinfections with other pathogens
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DAS181 was well tolerated with no major adverse events during therapy