A combined in vitro approach to improve the prediction of mitochondrial toxicants
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- 作者：Julie Eakins ; Caroline Bauch ; Heather Woodhouse ; Benjamin Park ; Samantha Bevan ; Clive Dilworth ; Paul Walker ; p.walker@cyprotex.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mitochondria ; Extracellular flux assay ; HepG2 ; Toxicity ; In vitro
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：34
- 期：Complete
- 页码：161-170
- 全文大小：806 K
文摘
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Assessment of two <em>in vitroem> assays to detect mitochondrial toxicity in HepG2 cells.
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Measurement of mitochondrial respiration, glycolysis and reserve capacity by XFe96.
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Potential mechanism of mitochondrial toxicity can be predicted using the extracellular flux assay.
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Combining Glu/Gal and extracellular flux assays improves predictivity of mitochondrial toxicants.