Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits

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• 作者：Che Anishas Che Idris^a ; ^b ; Tilakavati Karupaiah^b ; Kalyana Sundram^c ; Yew Ai Tan^a ; Nagendran Balasundram^a ; Soon-Sen Leow^a ; Nurrul Shaqinah Nasruddin^d ; Ravigadevi Sambanthamurthi^a ; ^{raviga@mpob.gov.my" class="auth_mail}
• 关键词：ABTS· ; + ; 2 ; 2&prime ; -azinobis (3-ethylbenzothiazoline) 6-sulphonic acid radical cation ; ANOVA ; analysis of variance ; CTR ; control ; Eo ; E-deficient ; Fe2+-TPTZ ; ferrous-2 ; 4 ; 6-tripyridyl-S-triazine ; Fe3+-TPTZ ; ferric-2 ; 4 ; 6-tripyridyl-S-triazine ; FRAP ; ferric reducing ability of plasma ; GAE ; gallic acid equivalent ; HDL-C ; high-density lipoprotein cholesterol ; LDL-C ; low-density lipoprotein cholesterol ; OPP ; oil palm phenolics ; RBD ; refined ; bleached ; deodorised ; TC ; total cholesterol ; TE ; Trolo
• 刊名：Journal of Functional Foods
• 出版年：March, 2014
• 年：2014
• 卷：7
• 期：Complete
• 页码：541-550
• 全文大小：580 K

文摘

The protective effects of oil palm vitamin E and phenolics against atherosclerosis, either singly or in combination, were studied in an atherogenic rabbit model. Rabbits were either fed atherogenic diet only (CTR), or atherogenic diet with vitamin E (VIT E), or atherogenic diet with oil palm phenolics (OPP), or atherogenic diet with both vitamin E and oil palm phenolics (VIT E + OPP). Results from lipid profile and antioxidant analyses were not significantly different between groups (p > 0.05). However, fibrous plaques were associated with the CTR group (8.90 卤 5.41%) and these were significantly less (p < 0.05) in the VIT E (2.88 卤 2.01%) and OPP (1.48 卤 4.45%) groups. Fibrous plaques were not detected at all in the VIT E + OPP group. Our findings suggest that oil palm vitamin E and oil palm phenolics individually inhibited atherosclerotic lesion development. However, oil palm vitamin E in combination with oil palm phenolics provided the highest protective effect against development of atherosclerotic lesions.