Depletion of macrophages in CD11b diphtheria toxin receptor mice induces brain inflammation and enhances inflammatory signaling during traumatic brain injury
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- 作者：Ryan A. Frielera ; b ; Sameera Nadimpallia ; Lauren K. Bolanda ; Angela Xiea ; Laura J. Kooistraa ; Jianrui Songa ; Yutein Chunga ; Kae W. Choc ; Carey N. Lumenga ; c ; Michael M. Wanga ; d ; e ; Richard M. Mortensena ; b ; f ; rmort@umich.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Macrophage depletion ; CD11b-DTR ; Traumatic brain injury ; Inflammation
- 刊名：Brain Research
- 出版年：2015
- 出版时间：22 October 2015
- 年：2015
- 卷：1624
- 期：Complete
- 页码：103-112
- 全文大小：2418 K
文摘
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Macrophage depletion increases inflammation after traumatic brain injury.
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Enhanced inflammation in macrophage-depleted mice does not affect lesion size.
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Macrophage depletion increases inflammation in select tissues in the absence of injury.