Evaluation of hydroxyapatite and β-tri calcium phosphate microplasma spray coated pin intra-medullary for bone repair in a rabbit model

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• 作者：Arjun Dey^a ; Samit Kumar Nandi^b ; ^{samitnandi1967@gmail.com} ; Biswanath Kundu^a ; ^{biswa_kundu@rediffmail.com} ; Chandrasekhar Kumar^b ; Prasenjit Mukherjee^b ; Subhasis Roy^b ; Anoop Kumar Mukhopadhyay^a ; Mithlesh Kumar Sinha^a ; Debabrata Basu^a
• 关键词：Hydroxyapatite ; β ; -Tri calcium phosphate ; Microplasma spraying ; In vivo animal trial ; Intramedullar pinning ; Bone defects healing
• 刊名：Ceramics International
• 出版年：2011
• 出版时间：May 2011
• 年：2011
• 卷：37
• 期：4
• 页码：1377-1391
• 全文大小：2386 K

文摘

Here we report a comparative study of the healing kinetics of surgically created artificial defects in the tibia of New Zealand white rabbits. Comparison of the healing kinetics was made for uncoated conventional SS316L intramedullary pins, and the same pins with microplasma sprayed (MIPS) pure hydroxyapatite (HAp) and beta-tri calcium phosphate (β-TCP) coatings. After thorough material characterizations including XRD, FTIR, SEM, etc., MIPS coated pins were implanted to such animals. Serum biochemistry, radiology and fluorochrome labelling were used to evaluate the comparative healing kinetics of these implants in vivo. In comparison to those of the uncoated pins, the pins coated with both MIPS HAp and β-TCP showed significant increment of alkaline phosphatase up to 15th postoperative day, insignificant changes in serum phosphorus and calcium with uneventful healing of bone defect. There was development of Havarsian canals and well-defined peripherally placed osteoblasts along with evidence of angiogenesis and comparatively more new bone formation in the defect site. On a comparative scale, the performance of the β-TCP coated intramedullary pins was much better than that of the pure HAp coated pins than the uncoated intramedullary pins.