Modeling and time-dependent dynamics of processes of stimulated depolymerization, auto-repairing, degradation and radiation curing of DNA macromolecules and biopolymers at separated and combined actio

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• 作者：Vysotskii ; Vladimir I. ; Pinchuk ; Anatoliy O. ; Kornilova ; Alla A. ; Samoylenko ; Igor I.
• 关键词：28.41.T ; 87.50.&minus ; a ; 87.50.Gi ; 87.50.Nq ; 87.50.Pr ; 87.53.&minus ; j ; Time-dependent dynamics ; Hormesis phenomenon ; Radiation antagonism ; DNA double breaks ; Low and large doses ; van der Waals dispersion interaction ; Coulomb interactions
• 刊名：Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
• 出版年：2001
• 出版时间：December, 2001
• 年：2001
• 卷：185
• 期：1-4
• 页码：108-115
• 全文大小：128 K

文摘

The time-dependent dynamics of the formation, relaxation and auto-repairing of double breaks of DNA macromolecules at the combined radiation action and non-radiation processes of degradation (e.g. by free radicals) were considered. The auto-repairing of DNA double breaks is connected with the peculiarities of long-range interaction of nucleotide charges, atoms and molecules in the intracellular milieu. The properties of intracellular liquid and the characteristics of force interaction between the end-pairs of nucleotides in the area of DNA break in response to radiation are changed. Each kind of radiation is characterized by a certain effectiveness of the double DNA break formation but simultaneously one creates the conditions for their liquidation. On the basis of the analysis and correlation of these processes the time-dependent theory for DNA degradation was created, including hormesis phenomenon, radiation antagonism, the validity of anomaly influence of low and large doses at sharp and chronic radiation and other effects. The qualitative and quantitative correspondences of the theory and experimental results of radiation biology were obtained.