Pressurised liquid extraction and liquid chromatography-high resolution mass spectrometry to determine high-intensity sweeteners in fish samples

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• 作者：Mireia Nú ; ñ ; ez ; Francesc Borrull ; Eva Pocurullup> ; up>up>eva.pocurull@urv.catup> ; Nú ; ria Fontanals
• 关键词：Sweeteners ; Pressurised liquid extraction ; Liquid chromatography-high resolution mass spectrometry ; Fish samples
• 刊名：Journal of Chromatography A
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：1479
• 期：Complete
• 页码：32-39
• 全文大小：949 K
• 卷排序：1479

文摘

First PLE/LC-HRMS (Orbitrap) method to determine high-intensity sweeteners in fish samples. Different clean-up strategies were evaluated to reduce the high matrix effect. In-cell clean-up with alumina and on-cell clean-up with hexane were selected. The method was validated in different fish species according to their lipid content.