Ivermectin and albendazole alone and in combination for the treatment of lymphatic filariasis in Ghana: follow-up after re-treatment with the combination

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• 作者：Samuel K. Dunyo ; Paul E. Simonsen
• 关键词：Author Keywords ; filariasis ; Wuchereria bancrofti ; microfilariae ; chemotherapy ; re-treatment ; drug combinations ; ivermectin ; albendazole ; disease control ; Ghana
• 刊名：Transactions of the Royal Society of Tropical Medicine and Hygiene
• 出版年：2002
• 出版时间：March - April 2002
• 年：2002
• 卷：96
• 期：2
• 页码：189-192
• 全文大小：552 K

文摘

The efficacy of re-treatment with the combination of ivermectin (150–200 μg/kg bodyweight) and albendazole (400 mg) on Wuchereria bancrofti microfilaraemia was assessed in 1997–1999 in 4 groups of individuals from coastal Ghana, which 1 year previously had received a primary treatment with placebo (n = 38), albendazole (n = 39), ivermectin (n = 34) or combination of albendazole and ivermectin (n = 42), respectively. One year after the re-treatment, an overall mean reduction in microfilarial intensity of 76·2 % in relation to the intensity before re-treatment was observed, with no statistical significant difference between the 4 groups. The groups given primary treatment with placebo or the drug combination showed re-treatment reductions which were lower (72·5 % and 69·8 % , respectively) but not statistically significantly different from the reduction observed 1 year after the primary treatment with the combination (86·7 % ). The efficacy of the combination treatment thus appeared to be largely independent of the type of primary treatment given and multiplicative when used repeatedly.