A study on the provocative day test effect of ivermectin and albendazole on nocturnal periodic Wuchereria bancrofti microfilaraemia

详细信息    查看全文

• 作者：Samuel K. Dunyo ; Francis K. Nkrumah ; Paul E. Simonsen
• 刊名：Transactions of the Royal Society of Tropical Medicine and Hygiene
• 出版年：1999
• 出版时间：November - December 1999
• 年：1999
• 卷：93
• 期：6
• 页码：608-610
• 全文大小：439 K

文摘

We conducted a randomized double-blind placebo-controlled study, in the Ahanta West District of Ghana, on the provocative day test effect of ivermectin and albendazole alone and in combination on nocturnal periodic Wuchereria bancrofti microfilaraemia. Sixty-three individuals with high night-time microfilaria (mf) intensities were identified in 1997 or 1998 and randomized into 4 groups. Blood samples for mf were then collected from the same individuals in the daytime (between 09:00 and 15:00) immediately before and 30–50 min after treatment. Groups 1–4 were treated with ivermectin alone (150–200 μg/kg), albendazole alone (400 mg), the combination of ivermectin and albendazole, and placebo, respectively. Intensities of mf in daytime samples were considerably lower than in night-time samples. Neither ivermectin or albendazole alone nor their combination provoked significant liberation of W. bancrofti mf into the peripheral circulation after the daytime treatment.