Epigenomic Deconvolution of Breast Tumors Reveals Metabolic Coupling between Constituent Cell Types
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- 作者：Vitor Onuchic1 ; 6 ; onuchic@bcm.edu" class="auth_mail" title="E-mail the corresponding author ; Ryan J. Hartmaier2 ; 7 ; David N. Boone2 ; Michael L. Samuels3 ; Ronak Y. Patel1 ; Wendy M. White4 ; Vesna D. Garovic5 ; Steffi Oesterreich2 ; Matt E. Roth1 ; Adrian V. Lee2 ; Aleksandar Milosavljevic1 ; 6 ; 8 ; amilosav@bcm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：cell type composition ; deconvolution ; breast cancer ; metabolic coupling ; heterotypic interaction ; DNA methylation ; gene expression ; Warburg effect ; cancer ; metabolism
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：17
- 期：8
- 页码：2075-2086
- 全文大小：4250 K
文摘
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EDec infers cell types within tissues and molecular profiles of constituent cells
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EDec deconvolutes molecular profiles of breast tumors within the TCGA collection
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EDec-estimated immune infiltration predicts prognosis for basal-like breast tumors
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Switch from adipose to fibrous stroma enhances oxidative metabolism of cancer cells