Pathophysiology of acute heart failure: A world to know

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• 作者：M. Sá ; nchez-Martelesp>ap>p> ; p>p>bp>p> ; p>p>marta.sanchez15@yahoo.es" class="auth_mail" title="E-mail the corresponding authorp> ; J. Rubio Graciap>ap>p> ; p>p>bp> ; I. Gimé ; nez Ló ; pezp>cp>p> ; p>p>dp>
• 关键词：Acute heart failure ; Pathophysiology ; Cardiorenal syndrome ; Venous congestion ; Inflammation ; Remodeling
• 刊名：Revista Clínica Española (English Edition)
• 出版年：2016
• 出版时间：January-February 2016
• 年：2016
• 卷：216
• 期：1
• 页码：38-46
• 全文大小：887 K

文摘

Our understanding of the pathophysiological mechanisms of heart failure (HF) has changed considerably in recent years, progressing from a merely hemodynamic viewpoint to a concept of systemic and multifactorial involvement in which numerous mechanisms interact and concatenate. The effects of these mechanisms go beyond the heart itself, to other organs of vital importance such as the kidneys, liver and lungs. Despite this, the pathophysiology of acute HF still has aspects that elude our deeper understanding.p><p id="spar0010">Hemodynamic overload, venous congestion, neurohormonal systems, natriuretic peptides, inflammation, oxidative stress and its repercussion on cardiac and vascular remodeling are currently considered the main players in acute HF.p><p id="spar0015">Starting with the concept of acute HF, this review provides updates on the various mechanisms involved in this disease.