Novel aqueous chitosan-based dispersions as efficient drug delivery systems for topical use. Rheological, textural and release studies
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- 作者：M.J. Lucero
- 关键词：Thiolated-chitosan ; Anhydrous theophylline ; Diltiazem hydrochloride ; Drug release ; Rheological characterization ; Hydrogels
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：692-699
- 全文大小：1511 K
文摘
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- <p id="par0005">A novel thiolated chitosan (CTS) useful as topical drug delivery systems is studied.p>
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- <p id="par0010">Theophylline (Th) and Diltiazem (Dt) were chosen as chemically diverse model drugs.p>
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- <p id="par0015">Aqueous dispersions were prepared with 1% or 3% w/v CTS and 0.5% w/v drug.p>
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- <p id="par0020">All flow curves fit the Herschel-Bulkley model with negative yields stress values.p>
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- <p id="par0025">Concentration of CTS and chemical nature of drugs are key factors in drug release.p>