- 作者：Julio A. Carbayo Herencia ; Marta Simarro Rueda ; Luis Miguel Artigao R¨®denas ; Juan A. Divis¨®n Garrote ; David Caldevilla Bernardo ; Isabel Ponce Garc¨ªa ; Carlos Sanchis Dom¨¨nech ; Todos intervienen en nombre del Grupo de Enfermedades Vasculares de Albacete (GEVA)
- 关键词：Mortalidad ; Inflamació ; n ; Fibrinó ; geno ; Factores de riesgo ; Epidemiologí ; a ; Pronó ; stico
- 刊名：Cl¨ªnica e Investigaci¨®n en Arteriosclerosis
- 出版年：2013
- 出版时间：April-June, 2013
- 年：2013
- 卷：25
- 期：2
- 页码：56-62
- 全文大小：339 K
Introduction
Inflammation is present in every stage of the atherosclerosis process, therefore, inflammation hallmarks such as the fibrinogen can be related to the complications in which it intervenes, mortality is one of them. The objective of this study is to assess the association of the fibrinogen with all-cause mortality in men from general population sample obtained by random sampling in the Spanish region of Albacete.
Methods
A total of 506 men without cardiovascular events with 10.6 years (SD = 2.3) of follow-up, volunteered to participate in a prospective cohort study. The assessment of the fibrinogen as a predictor variable has been calculated after adjusting it by age, hypertension, diabetes mellitus, obesity, total cholesterol, HDL-cholesterol/triglycerides ratio, and smoking habit applying a Cox regression model. The adjustment has been made by adding the fibrinogen to the model, as a qualitative variable (< 400 and ¡Ý 400 mg/dl).
Results
The average age of the participants was 46.6 years old (DE = 16.8). After the adjustment, the hyperfibrinogenemia (¡Ý 400 mg/dl) showed a hazard ratio (HR) for all-cause mortality of 1.85 (95 % CI: 1.05-3.26) and for cardiovascular mortality HR = 2.69 (95 % CI: 1.09-6.63).
Conclusions
In men without cardiovascular events of our study, fibrinogen was showed as an independent predictor of all-cause mortality and cardiovascular mortality.