• 作者：Julio A. Carbayo Herencia^a ; ^b ; ^{jacarbayoh@telefonica.net} ; Luis Miguel Artigao Ró ; denas^c ; Juan A. Divisó ; n Garrote^d ; David Caldevilla Bernardo^e ; Carlos Sanchis Domé ; nech^f ; Pilar Torres Moreno^g ; Todos los autores actú ; an en nombre del Grupo de Enfermedades Vasculares de Albacete (GEVA)
• 关键词：Mortalidad ; Enfermedad cardiovascular ; Aterosclerosis ; Í ; ndice tobillo brazo ; Estudio de cohortes
• 刊名：Cl¨ªnica e Investigaci¨®n en Arteriosclerosis
• 出版年：2011
• 出版时间：January-February 2011
• 年：2011
• 卷：23
• 期：1
• 页码：21-28
• 全文大小：188 K

Introduction

The aim of this study was to investigate the predictive value of the ankle-brachial index (ABI) in all-cause mortality and composite end-point all-cause mortality and cardiovascular morbidity in a sample of a general population.

Methods

We performed a prospective cohort study of 1143 individuals free of cardiovascular events followed up for 10.8 years (SD = 2.2). The ABI was stratified in two levels: less than 0.9 and between 0.9 and 1.4. The predictive variables included in the adjustment were sex, age (cut-off: 50 years), hypertension, diabetes, obesity, hypercholesterolemia (cut-off: 200 mg/dl), high-density lipoprotein-cholesterol (HDLc)/triglyceride ratio, smoking and hyperfibrinogenemia. Kaplan-Meier survival curves and multivariate Cox proportional hazards analysis were used.

Results

The mean age of the participants (56.8 % female) was 47.1 years (SD = 17.4), range 18-91 years. An ABI value < 0.9 was found in 6.9 % of the sample. After adjustment, an ABI of < 0.9 had a hazard ratio (HR) of 1.90 [95 % confidence interval (CI) 1.10-3.26] for all-cause mortality, and an HR of 1.69 (95 % CI 1.07-2.67) for composite all-cause mortality and cardiovascular morbidity.

Conclusions

In our population, an ABI < 0.9 was a risk factor independent of all-cause mortality and of composite all-cause mortality and cardiovascular morbidity after a follow-up of 10.8 years.