An analysis of the blood pressure and safety outcomes to renal denervation in African Americans and Non-African Americans in the SYMPLICITY HTN-3 trial
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- 作者：John M. Flack ; MD ; MPHa ; jflack47@siumed.edu" class="auth_mail" title="E-mail the corresponding author ; Deepak L. Bhatt ; MD ; MPHb ; David E. Kandzari ; MDc ; David Brown ; MDd ; Sandeep Brar ; MDe ; James W. Choi ; MDf ; Ralph D'Agostino ; PhDg ; Cara East ; MDf ; Barry T. Katzen ; MDg ; Lilian Lee ; PhDe ; Martin B. Leon ; MDh ; Laura Mauri ; MD ; MSci ; William W. O'Neill ; MDj ; Suzanne Oparil ; MDk ; Krishna Rocha-Singh ; MDl ; Raymond R. Townsend ; MDm ; George Bakris ; MDn ; for the SYMPLICITY HTN-3 Investigators
- 关键词：Renal denervation ; African American ; uncontrolled apparent treatment-resistant hypertension
- 刊名：Journal of the American Society of Hypertension
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：9
- 期：10
- 页码：769-779
- 全文大小：738 K
文摘
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The systolic blood pressure (SBP) change after renal denervation did not differ by race in SYMPLICITY HTN-3.
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The change in sham office SBP was, however, nearly twice as large in African Americans (AA) than non-AA.
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The ambulatory SBP response among sham subjects and the larger office sham SBP response in AA may represent increased post-randomization medication adherence.
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In multivariate analyses, sham SBP response appeared to be much larger in AA than non-AA prescribed a complex antihypertensive regimen.