Molecular responses of Walleye (Sander vitreus) embryos to naphthenic acid fraction components extracted from fresh oil sands process-affected water

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• 作者：Julie R. Marentette^a ; Kathleena Sarty^b ; Andrew M. Cowie^b ; Richard A. Frank^a ; L. Mark Hewitt^a ; Joanne L. Parrott^a ; Christopher J. Martyniuk^b ; ¹
• 关键词：Embryos ; Oxidative stress ; Apoptosis ; Deformities ; Oil sands ; OSPW ; NAFCs ; AEOs ; cyp1a
• 刊名：Aquatic Toxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：182
• 期：Complete
• 页码：11-19
• 全文大小：1679 K
• 卷排序：182

文摘

We exposed walleye embryos to naphthenic acid faction components (NAFCs). NAFCs were derived from fresh oil sands process-affected water. Newly hatched embryos were assessed for changes in expression of fourteen genes. NAFC exposure was associated with increased cyp1a1, and decreased gpx1b and rps40. Toxicity to walleye embryos may be linked to cytochrome P450 and oxidative stress.