- 作者：Elizabeth L. Bossart ; PhD&lowast ; ; EBossart@med.miami.edu" class="auth_mail" title="E-mail the corresponding author ; Radka Stoyanova ; PhD&lowast ; ; Kiri Sandler ; MD&dagger ; ; Matthew Studenski ; PhD&lowast ; ; Amber Orman ; MD&lowast ; ; Matthew Abramowitz ; MD&lowast ; ; Alan Pollack ; MD ; PhD&lowast ;
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：95
- 期：2
- 页码：827-834
- 全文大小：1218 K
Methods and Materials
Group 1 (n=20) patients were treated before the trial inception with the standard dose prescription. Each patient had an additional treatment plan generated per the experimental arm. A total of 40 treatment plans were compared (20 plans for each technique). Group 2 (n=15) consists of patients currently accrued to the hypofractionated external beam image guided highly targeted radiation therapy trial. Plans were created as per the treatment arm, with additional plans for 5 of the group 2 experimental arm with a 3-mm expansion in the imaging GTV.
Results
For all plans in both patient groups, planning target volume coverage ranged from 95% to 100%; GTV coverage of 89.3 Gy for the experimental treatment plans ranged from 95.2% to 99.8%. For both groups 1 and 2, the percent volumes of rectum/anus and bladder receiving 40 Gy, 65 Gy, and 80 Gy were smaller in the experimental plans than in the standard plans. The percent volume at 1 Gy per fraction and 1.625 Gy per fraction were compared between the standard and the experimental arms, and these were found to be equivalent.
Conclusions
The dose per fraction to the OARs can be made equal even when giving a large simultaneous integrated boost to the GTV. The data suggest that a GTV margin may be added without significant dose effects on the OARs.