The anti-proliferative effect of cation channel blockers in T lymphocytes depends on the strength of mitogenic stimulation
详细信息 查看全文
- 作者：Zoltan PethoaAuthor Vitae ; Andras BalajthyaAuthor Vitae ; Adam BartokaAuthor Vitae ; Krisztian BenebAuthor Vitae ; Sandor SomodicAuthor Vitae ; Orsolya SzilagyiaAuthor Vitae ; Eva RajnavolgyibAuthor Vitae ; Gyorgy Panyia ; panyi@med.unideb.hu" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Zoltan Vargaa ; dAuthor Vitae
- 关键词：CRAC ; Ca2+-release activated Ca2+ channel ; CD ; cluster of differentiation ; PI ; propidium iodide ; mTOR ; mammalian target of rapamycin ; FKBP ; FK506 binding protein ; Antx ; anuroctoxin ; 2-Apb ; 2-aminoethoxydiphenyl borate ; DI ; division index ; PBMC ; peripheral blood mononuclear cell ; CFSE ; carboxyfluorescein succinimidyl ester
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：171
- 期：Complete
- 页码：60-69
- 全文大小：2243 K
文摘
- •
A systematic study of T cell ion channel blockers inhibiting cell proliferation.
- •
Synergy may exist between ion channel blockers and rapamycin during inhibition.
- •
Increasing stimulation disrupts the anti-proliferative effect of the blockers.