Engraftment Efficiency after Intra-Bone Marrow versus Intravenous Transplantation of Bone Marrow Cells in a Canine Nonmyeloablative Dog Leukocyte Antigen-Identical Transplantation Model

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• 作者：Sandra Lange¹ ; Anne Steder¹ ; Doreen Killian¹ ; Gudrun Knuebel¹ ; Anett Sekora¹ ; Heike Vogel² ; Iris Lindner³ ; Simone Dunkelmann⁴ ; Friedrich Prall⁵ ; Hugo Murua Escobar¹ ; Mathias Freund¹ ; Christian Junghanss¹ ; ^{christian.junghanss@med.uni-rostock.de}
• 关键词：Intra&ndash ; bone marrow hematopoietic stem cell transplantation ; Allogeneic ; Nonmyeloablative conditioning ; Cell migration ; Dog
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：23
• 期：2
• 页码：247-254
• 全文大小：1533 K
• 卷排序：23

文摘

IBM application of HSC in a volume up to 25 mL is feasible in a canine model. IBM-injected cells remain in the injected bone but migrate also to other bones. IBM infusion might be superior for early engraftment compared with i.v. application. Method of graft processing seems to be important for successful engraftment in IBM HSCT.