Pediatric Miller Fisher Syndrome Complicating an Epstein-Barr Virus Infection

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• 作者：Cé ; line Communal ; MD^a ; Anne Filleron ; MD ; PhD^a ; ^b ; ^{anne.filleron@chu-nimes.fr" class="auth_mail" title="E-mail the corresponding author} ; Sandrine Baron-Joly ; MD^a ; Randa Salet ; MD^a ; Tu-Anh Tran ; MD ; PhD^a ; ^b
• 关键词：Infectious mononucleosis ; Miller-Fisher syndrome ; pediatric ; Epstein-Barr virus ; Guillain-Barré ; syndrome ; polyneuropathy
• 刊名：Pediatric Neurology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：63
• 期：Complete
• 页码：73-75
• 全文大小：177 K

文摘

Miller Fisher syndrome, a variant of Guillain–Barré syndrome, is an acute inflammatory demyelinating polyradiculoneuropathy that may occur weeks after a bacterial or viral infection. Campylobacter jejuni and Haemophilus influenzae are frequently reported etiological agents.

Patient Description

We describe a boy with Miller Fisher syndrome following Epstein-002DBarr virus primary infectious mononucleosis. He presented with bilateral dysfunction of several cranial nerves and hyporeflexia of the limbs but without ataxia. Miller Fisher syndrome was confirmed by the presence of anti-GQ1b antibodies in a blood sample. Epstein–Barr virus was identified by polymerase chain reaction and serology.

Conclusion

Epstein-Barr virus should be considered as a Miller Fisher syndrome's causative agent. The physiopathology of this condition may involve cross-reactive T-cells against Epstein-Barr virus antigens and gangliosides.