Dynorphin release by the lateral olivocochlear efferents may inhibit auditory nerve activity: A cochlear drug delivery study
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- 作者：Colleen G. Le Prella ; colleeng@ufl.edu" class="auth_mail ; cleprell@yahoo.com" class="auth_mail ; Larry F. Hughesb ; Sanford C. Bledsoe Jra
- 关键词：Lateral olivocochlear efferent ; Auditory nerve ; Cochlear whole nerve action potential ; Dynorphin ; Kappa opioid receptor
- 刊名：Neuroscience Letters
- 出版年：13 June 2014
- 年：2014
- 卷：571
- 期：Complete
- 页码：17-22
- 全文大小：1325 K
文摘
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The kappa opioid receptor agonist (−)pentazocine was applied to the cochlea.
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Sound evoked neural potentials were reduced in amplitude after drug treatment.
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Endogenous dynorphin at biologically plausible levels has an inhibitory effect.
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Higher (nonbiological) concentrations of drugs excite the auditory nerve.
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Transmitter effects should be assessed at biologically plausible concentrations.